The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding
Animal studies of effort-based choice behavior are being used to model effort-related motivational dysfunctions in humans.With these procedures, animals are offered a choice between high-effort instrumental actions leading to highly valued reinforcers vs.low effort/low reward options.Several previous studies have shown that dopamine (DA) uptake inh